ESM3
AI Model
Science
Current
A 98B-parameter language model that speaks protein.
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EvolutionaryScale's ESM3 (June 2024) treats protein sequence, structure and function as one token stream; the team used it to generate a novel fluorescent protein ('esmGFP') far from anything in nature. Open small versions seed academic use; the company spun out of Meta's dissolved protein team.
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Record reviewed as of 2026-01-15 — see Methodology.